The solution space of metabolic networks: producibility, robustness and fluctuations

Flux analysis is a class of constraint-based approaches to the study of biochemical reaction networks: they are based on determining the reaction flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the study of cellular metabolic networks. We briefly and selectively review the main approaches to this problem and then, building on recent work, we provide a characterization of the productive capabilities of the metabolic network of the bacterium E.coli in a specified growth medium in terms of the producible biochemical species. While a robust and physiologically meaningful production profile clearly emerges (including biomass components, biomass products, waste etc.), the underlying constraints still allow for significant fluctuations even in key metabolites like ATP and, as a consequence, apparently lay the ground for very different growth scenarios.Comment: 10 pages, prepared for the Proceedings of the International Workshop on Statistical-Mechanical Informatics, March 7-10, 2010, Kyoto, Japa

A cross impact methodology for the assessment of US telecommunications system with application to fiber optics development: Executive summary

A cross impact model of the U.S. telecommunications system was developed. For this model, it was necessary to prepare forecasts of the major segments of the telecommunications system, such as satellites, telephone, TV, CATV, radio broadcasting, etc. In addition, forecasts were prepared of the traffic generated by a variety of new or expanded services, such as electronic check clearing and point of sale electronic funds transfer. Finally, the interactions among the forecasts were estimated (the cross impacts). Both the forecasts and the cross impacts were used as inputs to the cross impact model, which could then be used to stimulate the future growth of the entire U.S. telecommunications system. By varying the inputs, technology changes or policy decisions with regard to any segment of the system could be evaluated in the context of the remainder of the system. To illustrate the operation of the model, a specific study was made of the deployment of fiber optics, throughout the telecommunications system

A cross impact methodology for the assessment of US telecommunications system with application to fiber optics development, volume 2

The appendices for the cross impact methodology are presented. These include: user's guide, telecommunication events, cross impacts, projection of historical trends, and projection of trends in satellite communications

A cross impact methodology for the assessment of US telecommunications system with application to fiber optics development, volume 1

A cross impact model of the U.S. telecommunications system was developed. It was necessary to prepare forecasts of the major segments of the telecommunications system, such as satellites, telephone, TV, CATV, radio broadcasting, etc. In addition, forecasts were prepared of the traffic generated by a variety of new or expanded services, such as electronic check clearing and point of sale electronic funds transfer. Finally, the interactions among the forecasts were estimated (the cross impact). Both the forecasts and the cross impacts were used as inputs to the cross impact model, which could then be used to stimulate the future growth of the entire U.S. telecommunications system. By varying the inputs, technology changes or policy decisions with regard to any segment of the system could be evaluated in the context of the remainder of the system. To illustrate the operation of the model, a specific study was made of the deployment of fiber optics throughout the telecommunications system

LoCuSS: The Near-Infrared Luminosity and Weak-Lensing Mass Scaling Relation of Galaxy Clusters

We present the first scaling relation between weak-lensing galaxy cluster mass, $M_{WL}$, and near-infrared luminosity, $L_K$. Our results are based on 17 clusters observed with wide-field instruments on Subaru, the United Kingdom Infrared Telescope, the Mayall Telescope, and the MMT. We concentrate on the relation between projected 2D weak-lensing mass and spectroscopically confirmed luminosity within 1Mpc, modelled as $M_{WL} \propto L_{K}^b$, obtaining a power law slope of $b=0.83^{+0.27}_{-0.24}$ and an intrinsic scatter of $\sigma_{lnM_{WL}|L_{K}}=10^{+8}_{-5}\%$. Intrinsic scatter of ~10% is a consistent feature of our results regardless of how we modify our approach to measuring the relationship between mass and light. For example, deprojecting the mass and measuring both quantities within $r_{500}$, that is itself obtained from the lensing analysis, yields $\sigma_{lnM_{WL}|L_{K}}=10^{+7}_{-5}\%$ and $b=0.97^{+0.17}_{-0.17}$. We also find that selecting members based on their (J-K) colours instead of spectroscopic redshifts neither increases the scatter nor modifies the slope. Overall our results indicate that near-infrared luminosity measured on scales comparable with $r_{500}$ (typically 1Mpc for our sample) is a low scatter and relatively inexpensive proxy for weak-lensing mass. Near-infrared luminosity may therefore be a useful mass proxy for cluster cosmology experiments.Comment: 9 Pages, 5 Figures, 3 Tables. Submitted to MNRA

Statistical mechanics of the mixed majority-minority game with random external information

We study the asymptotic macroscopic properties of the mixed majority-minority game, modeling a population in which two types of heterogeneous adaptive agents, namely ``fundamentalists'' driven by differentiation and ``trend-followers'' driven by imitation, interact. The presence of a fraction f of trend-followers is shown to induce (a) a significant loss of informational efficiency with respect to a pure minority game (in particular, an efficient, unpredictable phase exists only for f<1/2), and (b) a catastrophic increase of global fluctuations for f>1/2. We solve the model by means of an approximate static (replica) theory and by a direct dynamical (generating functional) technique. The two approaches coincide and match numerical results convincingly.Comment: 19 pages, 3 figure

Constraining the redshift evolution of the Cosmic Microwave Background black-body temperature with PLANCK data

We constrain the deviation of adiabatic evolution of the Universe using the data on the Cosmic Microwave Background (CMB) temperature anisotropies measured by the {\it Planck} satellite and a sample of 481 X-ray selected clusters with spectroscopically measured redshifts. To avoid antenna beam effects, we bring all the maps to the same resolution. We use a CMB template to subtract the cosmological signal while preserving the Thermal Sunyaev-Zeldovich (TSZ) anisotropies; next, we remove galactic foreground emissions around each cluster and we mask out all known point sources. If the CMB black-body temperature scales with redshift as $T(z)=T_0(1+z)^{1-\alpha}$, we constrain deviations of adiabatic evolution to be $\alpha=-0.007\pm 0.013$, consistent with the temperature-redshift relation of the standard cosmological model. This result could suffer from a potential bias $\delta\alpha$ associated with the CMB template, that we quantify it to be $|\delta\alpha|\le 0.02$ and with the same sign than the measured value of $\alpha$, but is free from those biases associated with using TSZ selected clusters; it represents the best constraint to date of the temperature-redshift relation of the Big-Bang model using only CMB data, confirming previous results.Comment: ApJ, in press. Manuscript matches the accepted version: 10 pages, 7 figures, 3 table

Typical properties of optimal growth in the Von Neumann expanding model for large random economies

We calculate the optimal solutions of the fully heterogeneous Von Neumann expansion problem with $N$ processes and $P$ goods in the limit $N\to\infty$. This model provides an elementary description of the growth of a production economy in the long run. The system turns from a contracting to an expanding phase as $N$ increases beyond $P$. The solution is characterized by a universal behavior, independent of the parameters of the disorder statistics. Associating technological innovation to an increase of $N$, we find that while such an increase has a large positive impact on long term growth when $N\ll P$, its effect on technologically advanced economies ($N\gg P$) is very weak.Comment: 8 pages, 1 figur